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Generic Drug Interactions

Sildenafil Citrate
Trusted Sildenafil Citrate component comes with the most notorious reactions, in combination with nitrates or similar products. If under any other medication consists of nitrates, ensure that you consult doctor before consuming ED med. Chest or heart patients are usually prescribed with Nitrate based medicine. To name a few: nitroglycerin include: Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid and others. Also, isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), isosorbide mononitrate (Imdur, ISMO, Monoket), amyl nitrate or nitrite (poppers) are other nitrate forms that could be a part of your medicine are to be avoided to combine with this ED solution. As, when nitrate combines with Sildenafil Citrate, it causes serious low blood pressure and shows up symptoms like dizziness, fainting, heart stroke.

Strictly restrict organic nitrates while taking Tadalafil composed ED medicine. This combination results in life-threatening reactions such as hypotension or extreme low blood pressure. Solutions composed of nitrate can only be consumed after at least 48 hours of Tadalafil medicine intake, under doctor’s guidance. Other sex drugs such as amyl nitrate, a form of organic nitrate should be avoided within the same time.

Some below listed chemical names and medicines that increase the levels of Tadalafil in your body, due to reactions they cause. This should be avoided by consuming lower levels of Tadalafil to overcome ED.

  • Ritonavir (Norvir)
  • Itraconazole (Sporanox)
  • Ketoconazole (Nizoral, Extina, Xolegel, Kuric)
  • Erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole, Ilosone)
  • Indinavir (Crixivan)

Contact doctor if you are consuming medicines containing nitrate or any nitrate form including:

  • Isosorbide dinitrate (Isordil)
  • Nitroglycerin (Nitro-Dur, Transderm-Nitro)
  • Isosorbide mononitrate (Imdur, Ismo, Monoket)

Aforementioned chemicals (with the medicines in which these chemicals are found) are mainly prescribed to heart patients suffering from Angina or like other issues. Undesirable reaction by coming together of Nitrates and Tadalafil is that it results in increase of heart rate, causing heart attack and very low blood pressure.

Drug interactions listed under this chemical component are general. It is difficult to always conclude the drug reactions, when combined with the other medications. This is because of the difference in body types and yet other variables including listed below once:

  • Grape fruit or grape fruit juice is known to create bad reactions in patients taking ED medicines that are composed of Vardenafil. This is because the reaction is a cause for increase of plasma concentrations of drug that are substrates of the CYP450 3A4 iso-enzyme
  • Alcohol (Ethanol) with Vardenafil risks very low blood pressure level and also increases hypotension, dizziness, head ache and increase in heart rate.


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